Full-length RTK assays
| Challenging targets, such as GPCRs and RTKs, are very attractive drug targets because they are easily accessible on cell surfaces. Yet, it is exactly this feature which makes assay development so difficult – these membrane proteins are usually not stable enough upon purification. We therefore invested in establishing RTK and GPCR assays to provide our clients with ready-made solutions, which require little investment. Our established biochemical assays enable measuring of affinities and kinetics of label-free ligand-RTK interaction. The assays leverage carefully optimized solubilization conditions that allow production of monodisperse RTK particles. Available for EGFR, Her2, Her3, FLT4, PDGFRb, EphB2, FGFR1 and C-MET. Please contact us for a quote. |